A cheap 3 mg chip is a unit, not a flat adult dose
Feeds treat 'a tablet' as the plan. The label treats body weight as the plan and the 3 mg chip as the unit you round to.
| Body weight | Strongyloides ~200 mcg/kg | 3 mg chips |
|---|---|---|
| 15-24 kg | 3 mg | 1 |
| 25-35 kg | 6 mg | 2 |
| 36-50 kg | 9 mg | 3 |
| 51-65 kg | 12 mg | 4 |
| 66-79 kg | 15 mg | 5 |
| 80 kg and up | 0.2 mg/kg | calculate |
Most adult Strongyloides work anchors near 200 micrograms per kilogram as a single oral dose. Onchocerciasis anchors near 150. A 60 kg person and a 95 kg person do not leave with the same stack. Absolute milligrams stay small, which is why the profile is gentle when the arithmetic is honest - and why a guessed stack is a bad idea.
Stromectol weight bands exist so a prescriber can turn mcg/kg into whole chips without a calculator argument at the counter. For Strongyloides, the labeled bands run 15-24 kg = 1 chip, 25-35 kg = 2, 36-50 kg = 3, 51-65 kg = 4, 66-79 kg = 5, then calculate at 0.2 mg/kg above that. Onchocerciasis uses a different band set because the mcg/kg target is lower. Same 3 mg unit. Different count.
Claim: cheap means you can eyeball it. Label: chips follow kilograms. Strike the flat-adult habit. File the band that matches the named infection. Trial backing for why those infections are on the card at all is in the trial review, not here.
Two labeled targets: 200 mcg/kg is not 150 mcg/kg
| Job | Target | Clock |
|---|---|---|
| Strongyloidiasis | ~200 mcg/kg | One dose; stool check; many repeat ~2 weeks |
| Onchocerciasis | ~150 mcg/kg | Yearly in MDA; as soon as 3 months individually |
| Scabies (off-label) | ~200 mcg/kg | Two doses, 1-2 weeks apart |
| Crusted scabies | ~200 mcg/kg | Multiple doses plus topical |
| Larva migrans | ~200 mcg/kg | Often one dose |
Intestinal strongyloidiasis: one oral dose designed to deliver about 200 mcg/kg, empty stomach, water. Extra doses are not routine on the label, but follow-up stool is. Many teams still plan a second pass around two weeks later because autoinfection can restock the gut. Immunocompromised hosts are not a one-chip story.
Onchocerciasis: one oral dose designed to deliver about 150 mcg/kg. Mass campaigns often repeat yearly. Individual care may repeat as soon as three months. Adults live in nodules for years; the tablet clears larvae and quiets output, then you come back. Treating a river-blindness patient on a Strongyloides chip count is the wrong target. Treating a Strongyloides patient on the lower onchocerciasis count is an underdose.
Scabies, off-label in the US, usually borrows the 200 mcg/kg figure and adds a second dose at 1-2 weeks because eggs hatch after the first pass. Crusted disease needs multiple rounds plus a topical. Cutaneous larva migrans often finishes in one weight-based dose. Head lice, when oral drug is used at all, follows a hatch-repeat logic and often stays behind a topical. Match the clock to the life cycle or 'did it work?' becomes guesswork.
Water on an empty stomach is part of the dose
Labels call for an empty stomach with water, at least an hour before food. That is how the microgram targets were studied, so that is the exposure the bands assume. At these amounts there is little room to 'make it easier' with breakfast and still claim you gave the studied dose.
A fatty meal can raise absorption, sometimes roughly doubling it. A few clinicians use that on purpose for a stubborn, supervised case. That is a deliberate exposure change, not a licence to swallow chips with dinner because you forgot. Unless the prescriber writes a fed plan, fasted dosing is the file.
Peak levels land around four hours. Parent half-life sits near 18 hours; most of the drug leaves in stool over days, not in urine. Those numbers explain why a single well-timed dose can cover a simple course - and why stacking extra chips 'to be sure' is not a harmless habit. CYP3A4 inhibitors and a theoretical P-glycoprotein issue belong on the med list you bring, not on a guess.
Repeat clocks follow eggs, adults, and autoinfection
One swallow finishes some jobs. Others fail on purpose if you skip the second date. The clock is biology, not a upsell.
Eggs and hatching mites are why scabies and some lice plans book a return. Adult Onchocerca worms are why river-blindness plans book a year. Autoinfection is why Strongyloides follow-up stool - and often a second dose - exists. If itch lasts two to four weeks after scabies treatment, that is often dead-mite debris, not proof you need an emergency third round. Fresh burrows are a different story.
Households and institutions fail when only the itchiest person is dosed. Treat contacts together. Hot-wash bedding on treatment days. Crusted disease is a specialist card: huge loads, longer courses, topical plus oral. Do not copy that card onto an ordinary case, and do not copy an ordinary two-dose card onto a crusted case.
Children under about 15 kg sit outside the usual labeled bands. Safety is not established the way it is above that weight. Pregnancy is a pause unless infection severity forces a shared decision. Those are hold marks on the card, not fine print you skip because the chip is cheap.
Mazzotti, Loa loa, and when geography holds the pen
At correct weight-based doses for a real parasite, most people feel little: mild dizziness, nausea, a day of ache. A heavy Onchocerca load can throw a Mazzotti reaction - itch, rash, tender nodes, fever, sometimes a blood-pressure drop - because larvae are dying, not because the tablet 'failed.' Ocular inflammation can follow larval death in the eye. Heavier loads mean fiercer flares.
In parts of Central and West Africa, Loa loa can circulate at high density. Ivermectin there can trigger a severe die-off with dangerous swelling and, rarely, encephalopathy. Programs count larvae in blood before mass rounds. Outside those zones, a scabies or Strongyloides patient rarely needs that workup. Lived or travelled extensively in the belt? Say so before anyone counts chips.
That exception does not make the tablet unsafe on a Manchester street. It makes geography part of the prescription. How the molecule reached campaign scale is a history file - the Kawana trail - not a dosing trick. This card only needs you to name the countries before the count.
Paste math fails a human kilogram on purpose
Horse and cattle products are built for animals that weigh hundreds of kilograms. A fingertip of paste can hold several safe human doses, plus excipients never studied as a human tablet. Eyeballing a syringe mark is not a conversion. Emergency departments saw the overdoses when viral posts treated livestock paste as a cheap 3 mg substitute. Confusion, vomiting, hypotension, seizures - that is barrier overflow, not a mystery toxin.
Human tablets, matched to weight, for a confirmed parasite: that is the safe line. No parasite, no upside. Veterinary paste, no conversion that a fact line will file. FDA language on livestock products at fda.gov is blunt because the arithmetic is blunt. Why COVID use failed the endpoint test is already in the trial review. This card only needs the product name to be Stromectol or a human generic, not a farm tube.
A Manchester card you can take to clinic
| Keep | Strike |
|---|---|
| Named parasite first | Chips 'just in case' |
| kg times 200 or 150 mcg | One chip for every adult |
| Empty stomach, water | A greasy meal as a default |
| Human 3 mg tablets | Horse or cattle paste |
| West/Central Africa history named | Skipping a Loa loa question |
Short checklist for the visit: name the parasite, weigh the person, pick 200 or 150 mcg/kg, convert to 3 mg chips on the matching band, take it fasted with water, book the repeat if eggs or adults demand it, flag Central or West African time if Loa loa is possible, and expect scabies itch to outlast the mites.
The two self-inflicted failures are livestock formulations and swallowing chips without a parasite on the card. Both add risk without a measured gain. Human tablets at the right weight, geography named, clocks booked - the tablet then does what decades of labeled use show. Discuss any change with your own clinician or pharmacist before you alter a dose. This desk files teaching lines, not a personal plan.